Ozona is a census-designated place (CDP) in and the county seat of Crockett County, Texas, United States. The population was 3,225 at the 2010 census. It is the only Census Bureau-recognized community in Crockett County, which is named for Colonel Davy Crockett, a hero of the Alamo.

Ozona is called the "Biggest Little Town in the World." It is located on Interstate 10 some 82 miles southwest of San Angelo. Crockett County is one of the nation's leading producers of wool and mohair. It is situated in the Edwards Plateau region in the western edge of the Texas Hill Country. Hunters come to Ozona in search of white-tailed deer, javelina, and game birds.

The county was organized in 1891 under a giant oak tree, which still stands and shades the historical marker describing the event. The Davy Crockett Monument is a large statue in the City Park on the town square. Across from the monument is the Crockett County Museum.

Ozona was known as Powell Well, after land surveyor E.M. Powell, when it was founded in 1891. In 1897, it was renamed Ozona for the high quantity of its open air, or "ozone". A flood in 1954 killed 16 people and destroyed about half of the homes in the town.